Bradley G. Phillips, Pharm.D., BCPS, FCCP
Millikan-Reeve Professor and Head
Director, Clinical and Translational Research Unit (CTRU)
Professor , University of Georgia 2007-Present
Associate Professor , University of Iowa 2001-2007
Director , Iowa GCRC Laboratory Core 2001-2007
Assistant Professor , University of Iowa 1995-2001
Clinical Pharmacist , VAMC-Iowa City 1995-2007
Fellowship-Cardiology , University of Illinois-Chicago 1993-1995
Doctor of Pharmacy , Medical College of South Carolina 1991-1993
Clinical Pharmacist , Lion's Gate Hospital 1990-1991
Pharmacy Resident , Lion's Gate Hospital 1989-1990
Bachelor of Science in Pharmacy , University of British Columbia 1989-1995
Obstructive sleep apnea affects 15 million Americans and occurs in up to 5% of men and 3% of women. The common characteristics of obstructive sleep apnea include obesity, male gender, large neck circumference, daytime tiredness, fatigue, and snoring. One of the hallmark signs of sleep apnea is witnessed cessation of breathing during sleep. Although obstructive sleep apnea occurs in children and adolescents, it is more common in middle-aged adults with prevalence increasing with age. A diagnostic sleep study (polysomnography) determines the severity or number of episodes of apnea and hypopnea during sleep. The main treatment to alleviate obstructive sleep apnea is continuous positive airway pressure therapy. This type of therapy is delivered by a bedside machine that provides room air through a small mask secured over the nose during the night.
There are well established pathophysiologic factors, such as obesity, that explain the development and progression of cardiovascular disease. Other known factors include activation of the central sympathetic nervous system, increases in circulating catecholamine levels, impaired cardiovascular variability, and activation of the endothelin system. These well known mechanisms for cardiovascular disease also occur in relatively healthy people that just have obstructive sleep apnea. Patients with severe sleep apnea who are free of cardiovascular disease have impaired endothelium dependent vasodilation. This type of vasculopathy is seen early in hypertension, diabetes, heart failure and in arteriosclerosis. The presence of obesity worsens sleep apnea. The corollary to this may also be true as patients with sleep apnea have increased leptin resistance and weight gain. It appears that many of the known factors for poor cardiovascular heath also occur in sleep apnea. Emerging evidence suggests that untreated sleep apnea may predispose to cardiovascular disease.
Areas of expertise in clinical and translational research include microneurography (MSNA, SSNA), endothelial function (conduit and resistance vessels), hyperinsulinemic euglycemic and hypoglycemic clamps, assessment of vasoactive peptides, ambulatory blood pressure monitoring, anthropometric measurements.
Dopp JM, Agapitov AV, Sinkey CA, Haynes WG, Phillips BG. Sildenafil Increases Sympathetically Mediated Vascular Tone in Humans. American Journal of Hypertension. Feb 26th 2013 (epub).
Board of Regents Commentary Qualifications of Pharmacists Who Provide Direct Patient Care: Perspectives on the Need for Residency Training and Board Certification. Pharmacotherapy 2013; April 26th.