Quicklinks

Harika Sabbineni, B.Pharm.D

CET Graduate Assistant

Office: HM Bldg., 914 New Bailie St., Augusta, GA, 30912, Rm

Education

Graduate Certificate Clinical Research Administration, Eastern Michigan University, Ypsilanti, MI 2012

Bachelor of Pharmacy , Jawaharlal Nehru Technological University, Kakinada, India 2011

Research Interests

Pulmonary arterial hypertension (PAH) is a progressive and fatal syndrome that has no cure and the existing treatment options continue to treat the symptoms rather than the root cause of the disease. My research interest involves studying endothelial to mesenchymal transition (EndMT), an underlying mechanism that contributes to the development of (PAH) and the signaling pathways involved in this process.

 

 

Selected Publications

Selected Publications
  1. Patel A*, Sabbineni H*, Clarke A, Somanath PR.  Novel roles of Src in cancer cell epithelial-to-mesenchymal transition, vascular permeability, microinvasion and metastasis. Life Sci. 2016 Jul 15;157:52-61.
  2. Gao F, Artham S, Sabbineni H, Al-Azayzih A, Peng XD, Hay N, Adams RH, Byzova TV, Somanath PR. Akt1 promotes stimuli-induced endothelial-barrier protection through FoxO-mediated tight-junction protein turnover. Cell Mol Life Sci. 2016 Apr 25.
  3. Sabbineni H*, Alwhaibi A*, Goc A, Gao F, Pruitt A, Somanath PR. Genetic deletion and pharmacological inhibition of Akt1 isoform attenuates bladder cancer cell proliferation, motility and invasion. Eur J Pharmacol. 2015 Oct 5;764:208-14.
  4. Abdalla M, Sabbineni H, Prakash R, Ergul A, Fagan SC, Somanath PR. The Akt inhibitor, triciribine, ameliorates chronic hypoxia-induced vascular pruning and TGFβ-induced pulmonary fibrosis. Br J Pharmacol. 2015 Aug;172(16):4173-88.
  5. Fairaq A, Goc A, Artham S, Sabbineni H, Somanath PR. TNFα induces inflammatory stress response in microvascular endothelial cells via Akt- and P38 MAP kinase-mediated thrombospondin-1 expression.  Mol Cell Biochem. 2015 Aug;406(1-2):227-36.
  6. Goc A, Sabbineni H, Abdalla M, Somanath PR. p70 S6-kinase mediates the cooperation between Akt1 and Mek1 pathways in fibroblast-mediated extracellular matrix remodeling. Biochim Biophys Acta. 2015 Jul;1853(7):1626-35.
  7. Shanab AY, Elshaer SL, El-Azab MF, Soliman S, Sabbineni H, Matragoon S, Fagan SC, El-Remessy AB. Candesartan stimulates reparative angiogenesis in ischemic retinopathy model: role of hemeoxygenase-1 (HO-1). Angiogenesis. 2015 Apr;18(2):137-50.
  8. Goc A, Al-Husein B, Katsanevas K, Steinbach A, Lou U, Sabbineni H, DeRemer DL, Somanath PR. Targeting Src-mediated Tyr216 phosphorylation and activation of GSK-3 in prostate cancer cells inhibit prostate cancer progression in vitro and in vivo. Oncotarget. 2014 Feb 15;5(3):775-87.
  9. Shivaram P, Ahmed MI, Kariyanna PT, Sabbineni H, Avula UM. Doppler echocardiography imaging in detecting multi-valvular lesions: a clinical evaluation in children with acute rheumatic fever. PLoS One. 2013 Sep 17;8(9):e74114. 

Posters and Presentations:

  1. Sabbineni H, Gao F, Artham S and Somanath PR. “Mechanisms regulating endothelial to mesenchymal transition (EndoMT) and vascular remodeling in pulmonary arterial hypertension.” UGA Center for Drug Discovery Conference, Athens, November 2015
  2. Sabbineni H, Goc A, Al-Husein B, Katsanevas K, Steinbach A, Lou U, Deremer DL and Somanath PR. “Targeting Src-mediated Tyr216 phosphorylation and activation of GSK-3 in prostate cancer cells inhibit prostate cancer progression in vitro and in vivo.” UGA Cancer Center Retreat, Athens, October 2015
  3. Sabbineni H, Abdalla M and Somanath PR. “Targeting Akt pathway ameliorates TGFβ-induced vascular pruning and pulmonary fibrosis via regulation of thrombospondin-1 expression.” FASEB-TGF-β Superfamily Conference, Snow Mass, CO, July 2015
  4. Sabbineni H, Yuhan Ji, Thi Tran and Somanath Shenoy. “Mechanisms regulating endothelial to mesenchymal transition (EndoMT) and vascular remodeling in pulmonary arterial hypertension.” STaR conference, Augusta, September 2014
  5. Sabbineni H, Goc A, Al-Husein B, Katsanevas K, Steinbach A, Lou U, Deremer DL and Somanath PR. “Targeting Src-mediated Tyr216 phosphorylation and activation of GSK-3 in prostate cancer cells inhibit prostate cancer progression in vitro and in vivo.” VA Research Day, Charlie Norwood VA Medical Center, Augusta, GA, May 2014
  6. Sabbineni H, Goc A, Al-Husein B, Katsanevas K, Steinbach A, Lou U, Deremer DL and Somanath PR. “Targeting Src-mediated Tyr216 phosphorylation and activation of GSK-3 in prostate cancer cells inhibit prostate cancer progression in vitro and in vivo.” Graduate Research Day, Georgia Regents University, Augusta, GA, March 2014
  7. Sabbineni H Goc A, Pruitt A, Somanath PR. “AKT 1 augments bladder cancer cell growth, motility and micrometastasis in vitro.” Graduate Research Day, University of Georgia, Athens, GA, August 2013
  8. Sabbineni H, Shanab AY, Elshaer SL, El-Azab MF, Soliman S, Matragoon S, Fagan SC and El-REmessy AB. “Candesartan preserves retinal vasculature via inhibition of iNOS expression in ischemic retinopathy” 5th Annual Retreat, Vision Discovery Institute, Georgia Regents University, Augusta, GA, March 2013
  9. Sabbineni H, Shanab AY, Elshaer SL, El-Azab MF, Soliman S, Matragoon S, Fagan SC and El-REmessy AB. “Vascular protective effects of candesartan in ischemic retinopathy.”  29th Annual Graduate Research Day, Georgia Regents University, Augusta GA, March 2013


Of Note

May 2016- Awarded 2nd place in People’s Choice Awards for poster presentation, VA Research Day, Augusta, GA
2012-Present: Graduate Assistantship, Clinical & Administrative Pharmacy, University of Georgia
2012: Intern, University of Michigan Cancer Center
2011-2012: National Scholars Program Graduate Assistantship
2011- Received Best Presentation Award, 23rd Annual Pharmaceutical Conference, 2011, India

 

Affiliations